5-AMINO-1MQ (5AM) – 10mg

5-Amino-1MQ (5AM)

5-Amino-1MQ (also known as 5AM) is a small-molecule research compound studied for its influence on cellular energy metabolism and NAD⁺ biosynthesis. It acts as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), which plays a key role in regulating intracellular nicotinamide levels and energy balance.

Quick Facts

• Name: 5-Amino-1-methylquinolinium (5-Amino-1MQ, 5AM)
• Formula: C₁₂H₁₃N₅
• Molecular Weight: ~227 g/mol
• CAS Number: 163889-63-4
• Form: Lyophilized powder
• Storage: Store dry powder at −20 °C. Once reconstituted, keep refrigerated at 2–8 °C for up to 30 days.

Mechanism of Action

5-Amino-1MQ functions as a selective NNMT inhibitor. Inhibition of NNMT elevates intracellular nicotinamide concentrations, supporting higher NAD⁺ availability for essential cellular processes related to mitochondrial efficiency, oxidative metabolism, and energy regulation. This makes 5-Amino-1MQ a valuable model compound for exploring metabolic control and redox balance in laboratory research.

Research Focus

• Energy metabolism and mitochondrial function studies
• Adiposity and lipid regulation research
• Insulin sensitivity and glucose utilization models
• NAD⁺ biosynthesis and cellular aging pathways

Experimental Insights

In published preclinical studies, 5-Amino-1MQ has demonstrated potential to influence adipose tissue mass and metabolic efficiency through NNMT inhibition. Its small-molecule profile allows for broad use in cell culture, biochemical, and in-vivo metabolic research frameworks.

Reconstitution Guidelines

Reconstitute using sterile bacteriostatic water. Add the desired volume slowly while swirling gently until fully dissolved. Store the reconstituted solution at 2–8 °C and use within 20–30 days.

Technical Information

• Synonyms: 5-Amino-1-methylquinolinium, 5AM
• Purity: ≥99% (HPLC verified)
• Appearance: White crystalline or lyophilized powder
• Solubility: Soluble in sterile water or DMSO

References

• Kraus D. et al. “Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.” Nature Chemical Biology, 2014.
• Ulanovskaya O.A. et al. “NNMT promotes epigenetic remodeling in cancer cells through methylation control.” Nature Chemical Biology, 2013.
• PubChem Database – 5-Amino-1MQ (CID 102224577) , U.S. National Library of Medicine.

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